The following are known Action Replay Codes for Duke Nukem 3D on SEGA Genesis / Mega Drive (Genesis).

The codes should work with the region specified but may work for other regions as well.

Device Compatibility: Action Replay

• Infinite Health
  FF5573:64
  Note: You can still die by explosions.
• Run Mode Toggle (0-1)
  FF5541:XX
• Weapon Effect Modifier
  FF5597:XX

  Ever want to fire shotgun bullets with your boot? Put the value you desire into the weapon you wish to fire. No matter which weapon you choose, you must use an infinite ammo code for it.

  00 – Boot
  01 – Pistol
  02 – Shotgun

Infinite Ammo Codes
Using these codes without having the weapon will cause two side-effects: You will have access to the gun with infinite ammo and eventually the weapons will become invisible. (They will still be usable after that happens.)

• Infinite Ammo: Pistol
  FF5567:64
• Infinite Ammo: Shotgun
  FF5568:64
• Infinite Ammo: Triple Shotgun
  FF556A:64
• Infinite Ammo: Rocket Launcher
  FF556C:64
• Infinite Ammo: Pipe Bombs
  FF556E:64
• Infinite Ammo: Rocket Launcher 2X
  FF5570:64