The following are known Game Genie Codes for Spider-Man: Return of the Sinister Six on SEGA Game Gear.

• Begin With Web Fluid
  003 39F 5D4
• Start With Less Energy
  013 35F C4A
• Start With More Energy
  0A3 35F C4A
• Start With A Lot More Energy
  0F3 35F C4A
• Gives You 2,540 Points
  FF3 2FF E6E
• Start With 5 Continues
  063 1DF E66
• Start With 8 Continues
  093 1DF E66
• Infinite Energy
  3A4 0DD 2A2