The following are known Game Genie Codes for Teenage Mutant Ninja Turtles III: The Manhattan Project on Nintendo Entertainment System (NES).

• AENKLZPA
  Infinite lives
• AEOAALLA
  Start with 1 life
• IEOAALLA
  Start with 6 lives
• AEOAALLE
  Start with 9 lives
• SLXUTXVS + SLKXPKSO
  Infinite energy
• AAESYXAA
  No energy loss from using turbo attacks
• ALUGVYAG
  High-Jump
• AZUGVYAK
  Super-Jump
• AZUGVYAG
  Mega-Jump
• SXNSKKVK
  Infinite continues
• PAUZOGLA
  Start with 1 continue
• PAUZOGLE
  Start with 9 continues