The following are known Game Genie Codes for Joe & Mac on Nintendo Entertainment System (NES).

• PEUXYALA
  Start with 1 life as Player 1
• IEUXYALA
  Start with 5 lives as Player 1
• YEUXYALA
  Start with 7 lives as Player 1
• PEUXYALE
  Start with 9 lives as Player 1
• SZNXTEVK
  Infinite lives for both Player 1 & 2
• SZKVOKVK
  Protection from most enemy hits
• SXUVYVVK
  Protection from water
• AEXZGLAO
  Start with 1/2 energy (You will die when the energy bar is 1/2 empty)
• AAKUEAPE
  Stone Axe and Flint do more damage to bosses
• YAKUEAPE
  Stone Axe and flint do a lot more damage to bosses
• AASLOAZE
  Stone Wheel and Boomerang do more damage to bosses
• APSLOAZA
  Stone Wheel and Boomerang do a lot more damage to bosses
• APSLVAGA
  Fire does more damage to bosses
• AZSLVAGA
  Fire does a lot more damage to bosses
• SZVTKUSE
  Apples and Hamburgera are worth nothing
• AAVTULAO
  Apples and Hamburgera restore energy to 1/2
• OVUXZAET
  Start with the Stone Wheel instead of the Stone Axe as Player 1
• XVUXZAET
  Start with Flint instead of the Stone Axe as Player 1
• UVUXZAET
  Start with Fire instead of the Stone Axe as Player 1
• KVUXZAET
  Start with the Boomerang instead of the Stone Axe as Player 1
• ZEKZGAAA
  Start somewhere on level 2