The following are known Game Genie Codes for Defender II on Nintendo Entertainment System (NES).

• Infinite Lives
  GXTGEY
• Infinite Smart Bombs
  GXYSGI
• Start With 1 Life
  PELGNY
• Start With 6 Lives
  TELGNY
• Start With 9 Lives
  PELGNN
• Super Speed
  YAZVPG
  YETVIL
• Invincibility
  SXVIOTSA