The following are known Game Genie Codes for Two Crude Dudes on SEGA Genesis.

• Start With 6 Lives (Each Player)
  A2BA-AAFT
• Start With 7 Lives (Each Player)
  B6BA-AAFT
• Start With 8 Lives (Each Player)
  BABA-AAFT
• Start With 9 Lives (Each Player)
  BEBA-AAFT
• Start With 6 Continues
  A2BA-AAFJ
• Start With 7 Continues
  A6BA-AAFJ
• Start With 8 Continues
  BABA-AAFJ
• Start With 9 Continues
  BEBA-AAFJ
• Start On Level 2
  AJ0A-AABG
• Start On Level 3
  1AN0A-AABG
• Start On Level 4
  1AT0A-AABG
• Start On Level 5 – First Part
  1AY0A-AABG
• Start On Level 5 – Second Part
  1A20A-AABG
• Enemies Do Not Hurt
  AWYT-AA22
• Disc Cutter Is Easier To Kill
  AHDT-CAAC
• Disc Cutter Is Harder To Kill
  A5DT-CAAC
• Hunchback Is Easier To Kill
  AHDA-CAGA
• Hunchback Is Harder To Kill
  A5DA-CAGA
• Commander Is Easier To Kill
  AHDA-CAG0
• Commander Is Harder To Kill
  CDDA-CAG0
• Heavy Snake Is Easier To Kill
  AHDT-CAE6
• Heavy Snake Is Harder To Kill
  DXDT-CAE6
• Grease Monkey Is Easier To Kill
  AHDA-CAFL
• Grease Monkey Is Harder To Kill
  C5DA-CAFL
• Master Reaper Is Easier To Kill
  AHDT-CAFN
• Master Reaper Is Harder To Kill
  D5DT-CAFN
• Rabid Hounds Are Easier To Kill
  AHDA-CAHN
• Rabid Hounds Are Harder To Kill
  CDDA-CAHN
• Mad Bomber Is Easier To Kill
  AHDT-CAA2
• Mad Bomber Is Harder To Kill
  CDDT-CAA2
• Cyborg D Is Easier To Kill
  AHDT-CAC4
• Cyborg D Is Harder To Kill
  DDDT-CAC4
• Hand Sniper Is Easier To Kill
  AHDT-CADT
• Hand Sniper Is Harder To Kill
  D9DT-CADT
• Rhino-Man Is Easier To Kill
  AHDT-CAGJ
• Rhino-Man Is Harder To Kill
  EDDT-CAGJ
• Santa Imposter Is Easier To Kill
  AHET-CAAW
• Santa Imposter Is Harder To Kill
  DMET-CAAW
• Pyromaniac Is Easier To Kill
  AHFT-CAGW
• Pyromaniac Is Harder To Kill
  DDFT-CAGW