The following are known Game Genie Codes for Caliber .50 on SEGA Genesis.

• Master Code – Must Be On
  AJBT-AA4Y
• Infinite Grenades
  AB9A-BE5N
• Start With 99 Grenades
  XGHT-AAF2
• Grenade Pick-Up Adds 5 Instead of 10
  AYMT-KA2L
• Grenade Pick-Up Adds 1 Instead of 10
  AEMT-KA2L
• Infinite Lives
  AB4A-AA2Y
• Almost Invincible
  RZ5T-A6YJ
• Power Up Happens 2X As Fast
  ATMT-KA2A
• Power Up Happens 4X As Fast
  BAMT-KA2A
• Start And Restart With Full Power – Normal Level Only
  BWJA-B8WL
• Start And Restart With Full Power – Difficult Level Only
  BGJA-B8W2