The following are known Game Genie Codes for Spide-Man 2 on Nintendo Game Boy.

• FA6-FBE-4C1
  Infinite Lives
• 00F-78E-E66
  Start with 1 Life
• 04F-78E-E66
  Start with 5 Lives
• 09F-78E-E66
  Start with 10 Lives
• FA6-C4E-4C1
  Infinite Energy
• 01F-5BE-195
  Start with 1 Energy Point
• 016-EEE-195
  1 Energy Point after Life lost
• FAD-F6E-4C1
  Infinite Web Power
• 04F-73E-B3A
  *Start with 4 Web Points on 1st Life
• 05F-73E-B3A
  *Start with 5 Web Points on 1st Life
• 09F-73E-B3A
  *Start with 9 Web Points on 1st Life